Developed by Science with Compassion for Nature 

In  vitro  Plant-tech  is  a  research  derived  company,  specialising  in  development and production of innovative active ingredients and extracts  using the plant  cell  cultivation technology. This  enables sustainable  production  of  uniform,  customised, high quality plant material for the Cosmetic, Nutraceutical and Pharmaceutical industries.

To ensure  maximum  effectiveness,  we  perform  a  science-based  plant selection. Our metabolic enhancement  platform  will result in an optimised  production and  high accumulation of  bioactive  substances.  All  our  extracts are standardised to concentration and activity.

CDMO services

Customised Client Exclusive Cell Lines and Extracts

Choose the plant or the properties you want to target and let us do the rest. We will help you select plants and develop  tailor made cell lines rich in bioactive components.

These   assignments   are   customised   according  to  your  needs.        Invitro  Plant-tech   will   act as  your  contract   development  and manufacturing  organisation (CDMO).  You  will own all intellectual property rights for the selected plant and developed cell lines.

In-house extracts and cell lines

Our Own Developed Extracts 

High quality and sustainable extracts, standardised to concentration and activity. We standardise our extracts to guarantee consistent quality and perform a science based plant selection to ensure superior extracts from plants that are safe to use, targeted metabolite composition and with high efficacy.

Rhodiola rosea (Roseroot) Plant Stem Cell Extract stem cells

A POTENT MEDICINAL PLANT

The roseroot plant stem cell extract has a strong protective and antioxidant activity. The extract strengthens the cells from within by increasing the activity of antioxidant genes, such as SOD2 (Super Oxide Dismutase). It also increases skin radiance, as well as elasticity, firmness and skin structure. The extract enables healthy ageing of the skin, both through its protective and strengthening effects, as well as by boosting the activity of genes involved in skin structure, ECM (extracellular matrix) and cytoskeletal integrity in dermis. The extract contains several flavonoids, such as kaempferol and caffeic acid, well known for their photoprotective, anti-inflammatory, antioxidant and anti-ageing properties. Caffeic acid prevent photo ageing and UV induced erythema.

HISTORICAL USE

Roseroot has been used since ancient times for its apoptogenic properties. The plant was used by the Vikings for healing, and to improve strength and endurance. It was described by Dioscorides, the father of pharmacology, 77 C.E. in De Materia Medica and has a positive effect on sensitive skin, improves skin and over all skin conditions.

Calendula officinalis (Pot Marigold) Petal Derived Callus Extract

OUR FIRST FLOWER DERIVED CALLUS EXTRACT

Our Calendula plant stem cell extract strengthens the skin and provides topical protection through antioxidant and anti-irritant activities. This callus extract is developed from the petal tissue. Petals are one of the four components in the flower. This cell line is an intermediate between a flower extract and a plant stem cell extract and produces some actives that are found in undifferentiated Calendula cells and some specific to the flower. The extract is high in phenolics and contain the phenolic coumarin scopoletin, which has been reported to have therapeutic and chemo preventive effects, as well as anti-irritant, protective and antioxidant effects.

HISTORICAL USE

Pot marigold, one of the oldest of all cultivated flowers, was used by Ancient Egyptians to rejuvenate the skin. The flowers were also used in battlefields, to treat open wounds, as antiseptic and to promote healing. The plant has also been used to treat various skin ulcerations and eczema and is high in phenolics and flavonoids. Our Calendula extract has been boosted by subcomponent feeding to further stimulate production of phenolics, and has strengthening, astringent and rejuvenating properties.

 Althaea officinalis (Marshmallow) Plant Stem Cell Extract   Ghhh

ENTOURAGE EFFECT FOR PREVENTION

Our marshmallow plant stem cell extract has a rich composition of phenolics, such as scopoletin and caffeic acid, that together with other actives will have an entourage effect. Scopoletin is phenolic coumarin, well known for its therapeutic, chemoprotective, anti-irritant, anti-inflammatory, anti-ageing and antioxidant effects. Caffeic acid has anti-inflammatory, emollient and anti-ageing properties, prevents photo-ageing and UV induced erythema. We have used subcomponent feeding of the cell cultures, where building blocks of selected precursors were added, to further evolve and strengthen the phytochemical profile. The extract has high concentration of phenolics and has strong anti-oxidative effects.

HISTORICAL USE

Althea officinalis has been used since ancient times to treat inflammation, irritation and for its wound healing activities. Althea comes from the Greek word “to cure” and officinalis means that it is used in medicine. The plant has been described in many historical texts, was used in ancient Egypt for its medicinal properties, and by the ancient Greeks and Romans to treat a broad range of ailments, particularly for its soothing effects. The plant has anti-inflammatory, antioxidant and as well as an antibacterial activity.

PS Protection, Aloe vera Plant Stem Cell Extract hhhhhhhhhhh

ALOE VERA FOR PROTECTION AGAINST POLLUTION

PS Protection shows strong anti-pollution properties, strengthen and protects the cells from the negative impact of pollutants in the environment. It contains several potent flavonoids, such as kaempferol and quercetin, which are well known for their photoprotective, anti-inflammatory, anti-ageing, emollient and antioxidant properties. The extract is enriched with polysaccharides, which has been reported to support the skin immunity function. It restores the oxidative stress balance in the cells and promotes cell rejuvenation.

HISTORICAL USE

Within skin care Aloe vera has been used since ancient times as a soothing, moisturising and cooling agent. It is said that Cleopatra was using Aloe vera in her daily beauty routine. Aloe vera has a long history of use for a wide range of ailments and is one of the most famous medicinal plants. It has been used within traditional medicine as well as within Ayurvedic medicine and homeopathy. The plant is traditionally used for treatments of both internal and external ailments.

In-house extracts and cell lines

“We are fascinated by plants and their unique ability to produce powerful active ingredients with beneficial effects. Through our sustainable plant cell cultivation platform, it  is  possible to produce  high  quality  plant extracts  with  care and compassion for nature."                                                                                                                           Anna Holefors PhD, Founder and CEO of In vitro Plant-tech AB

Plantago major (Greater Plantain) Plant Stem Cell Extract

HEALTHY AGEING AND SKIN STRENGTHENING

Our greater plantain plant stem cell extract provides healthy ageing, strengthen the skin through increased elasticity, firmness and skin structure. The extract is high in phenolics and tannins. Tannins are known for their antimicrobial, antifungal and anti-inflammatory properties. It has been confirmed that tannins bind with macromolecules on the skin surface (e.g with proteins), creating a protective layer, what can be beneficial for treating skin disorders, promoting the healing process of wounds and burns. Tannins have been shown to act as astringent, thus they play an important role in skin firmness, tightening the skin and minimising the visibility of skin pores.

HISTORICAL USE

Greater plantain is an old medicinal plant well known for its wound healing properties and to treat skin disorders. It was used by the Vikings and was listed as one of ‘Nine Sacred Herbs’ the by the ancient Saxons. The plant has anti-inflammatory, antimicrobial, analgesic and antioxidant properties. In addition, some of the triterpenoids that are present in the plant, has been shown to increase the concentration of ceramides and collagen in skin cells.

Silybum marianum (Milk thistle) Plant Stem Cell Extract bbbb

HEALTHY AGEING AND DNA PROTECTION

Our Milk thistle plant stem cell extract has a high content and rich composition for phenolics and flavonoids. The extract is rich in tannins, which are one of the key players in skin protection, through their ability to form a protective layer on the skin. They also act as astringents, thus play an important role in skin firmness, tightening the skin and minimizing the visibility of skin pores. The milk thistle plant stem cell extract also contains the ferulic acid, a simple phenolic compound with strong antioxidant activity, known for its healing, photo protective, anti-inflammatory, anti-ageing, anti-hyperpigmentation, with protective and effects that promotes cell regeneration. Furthermore, the extract has DNA protective and soothing activities. 

HISTORICAL USE

Milk thistle, also called blessed milk thistle, was described already by the Romans and Greeks and has been used for centuries against liver related diseases, boils, and skin diseases. The plant is also used as a cell protectant, for wound healing, treatment against acne, rosacea and to increase moisture.

Flower Power Innovation flower power innovation power

COMBINES THE POWER OF FLOWERS WITH THE PLANT STEM CELL TECHNOLOGY

FLOWER POWER INNOVATION combines two superior plant extracts: the milk thistle (Silybum marianum) plant stem cell extract from milk thistle and petal derived callus (PDC) extract from pot marigold (Calendula officinalis). The extract supports a healthy ageing, increase elasticity and protects the skin. The extract is rich in tannins, which can create a protective layer on the skin, thereby playing an important role in skin firmness, tightening of the skin and minimizing the visibility of pores. The extract also contains interesting simple phenolics, such as ferulic acid, and flavonoids, such as scopoline, which provide healthy ageing through their protective roles.

Flower petals are know for their delicacy, beauty, bright colouration and aroma  - so delicate, but still so strong.

BACKGROUND: Different plant species produce different active substances. Furthermore, within the plant different substances may form depending on cell maturation grade and surrounding tissue. By selecting cells from a specific part of the plant, such as a leaf or flower, certain active substances can be produced in the cells and later extracted. 

Under Development


We are continuously working to establish new cell lines......

Technology

Reliable and Sustainable production

A large portion of plant raw material available on the market is still produced through traditional methods: harvesting of wild populations, field and greenhouse cultivation. It is estimated that about 70% of plant collections are performed by destructive harvesting, leading to endangerment of wild populations*. Field and greenhouse cultivation use large amounts of water and often includes usage of pesticides. Plant raw material produced in this way can also have low and varying quality.

Plant cell cultivation is a sustainable method that enables continous production, only requires a small part of one individual to build up a full population and therefore does not deplete the natural populations. No pesticides are used during production and it uses less water as compared to field cultivation. It is a continuous cultivation with full traceability and control, and is not affected by variations in weather or seasonal changes. Cell cultures are also often produced much faster and at a higher quality as compared with traditional cultivation in field. It also enables production of specific actives and to obatined an overall enriched production of metabolites.

*Report of the Task Force on Conservation & Sustainable use of Medicinal Plants, Government of India, Planning Commission, 2000

Quality and sustainability

Quality and Sustainability

We focus on having the best  products and assortment on  the market. Our  products are quality  assured  through  metabolic profiling, quantity of defined marker substances and microbial control. 
  • How to ensure high activity and availability of the active components in our extracts?

    When you prepare an expresso, you need to grind the beans and infuse the powder to release the flavours and actives. Likewise, in an extract the active components are made available and concentrated during the extraction process. Because of the roboust nature of the cell walls and organelles in plant cells, the active components are not always available unless an extraction process is performed. 

  • What does extract concentration mean?

    Similar to the fact that an expresso is a concentrated form of coffe, botanical extracts can be more or less concentrated. The concentration for extracts are often presented as mg dry extract/kg extract in carrier , where the carrier can be glycerol or similar. A 10% extract concentration will correspond to 100 mg dry extract/kg extract in carrier, whereas a 0.5% extract will correspond to 5 mg dry extract/kg extract in carrier. 

Quality and Sustainability
  • Why do we standardise our extracts?

    For botanical extracts it is important that the composition and activity is consistent. An extract that is standardised to activity will always have the same efficacy from batch to batch, ensuring reproducible results. For extracts that are not standardised to activity, there activity can vary over time. It is therefore important to perform standardisation both to concentration and activity.

  • How do we maximise sustainability?

    For us, ensuring sustainability is essential. We actively work with the three pillars of sustainability and are guided by Agenda 2030 and the Sustainable Development Goals (SDGs)**. We continuously improve and learn by 

    • selection of sustainable ingredients, sourcing and suppliers

    • optimisation of all assays and processes

    • using renewable enegry sources

    •  performing carbon footprint analysis

    • COSMOS certification of in house extracts 

    • selecting carbon neutral shipments

    • General guidance to SDG1-17 

    • In depth work regarding SDG4-Quality Education, 13-Climate Action and 15-Life on Land

    ** Diesendorf, 2000; Benn et al., 2014;  https://sdgs.un.org/goals

Quality and Sustainability
  • What is an active substance?

    An active substance is a molecule with a biological activity, such as antioxidant or antiinflammatory. Active substances can be incorporated into creams, liquids or tablets and used to treat specific ailments.

  • Why are plants so good at producting actives?

    Upon a rainy day we are able to go inside for protection. Unlike us plants are not able to move and therefore have to find other ways to respond to environmental changes and stress. Through evolution plants have adapted to produce a wide range of active subtances to help cope with stress and disease situations. Some actives have strong health beneficial, anti-inflammatory and regenerative properties, whereas other can have antimicrobial or anticancer properties.

    Different plants have evolved to produce different types of actives, where some will be specific to certain species. Furthemore, some of the actives will be produced in specific parts of the plant, such as leaves, flowers or roots.

  • What is a plant stem cell?

    A plant stem cell is a cell that is in the first development phase and has not yet started to differentiate. It will produce some actives that are specific to this developmental phase and some that are more general. The scientific name of a plant stem cells is undifferentiated callus cells. 

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Contact information

In vitro Plant-tech

Geijersgatan 4B, 216 18 Limhamn, Sweden

Geijersgatan 4B

+46705870682

info@invitroplanttech.se